It's 1861 and Buck gets the business men of Sacramento to establish the Pony express. Hawley runs the stage line over the same route and has the U. S. mail contract. When it looks like the Pony Express will be awarded the mail contract, he gives guns to the Indians and has them attack both the riders and the stations.

Truck drivers Steve Hackett and Bill Purvis are fired from their jobs with the West Coast Trucking company for not using second-gear going down steep grades. Davis, the company vice-president, surprisingly asks them to carry a load of merchandise to Arrowhead and offers a $1000 bonus. He tells them it is a load of lettuce. Several miles out of Los Angelese, they are stopped by a mob of lettuce-farm workers on strike. When the first crate is tossed off the truck, it explodes and the two pals learn their merchandise is a cargo of dynamite. The workers let them proceed and they crash into a car driven by Mary Stevens, whom they had met at a restaurant. She and her dog, "Butch" (played by a Credited dog named Stooge), join them and they deliver their cargo, and learn unscrupulous real-estate operators have jammed the locks on the dam in order to ruin the ranchers and farmers and take over their property.

In this Western, comprised of 12 chapters from a serial, Kit leads a group carrying a large gold shipment across the wild West. When the Mystery Riders attack and steal the gold, Kit is the only survivor. He later joins forces with the cavalry to retrieve it.

The Three Mesquiteers are forced to track down a train robbery ring after some of the gang hijack their truck for a getaway and the police conclude they are part of the gang, an identification which is just fine with the gang's nameless chief.

Pete Marlan is a gambler with an unsavory past. Suspected of being an outlaw, Pete plays along with this misconception, the better to infiltrate a gang of smugglers. Along the way, he clears the name of the brother of Texas Ranger Mike Donovan, and helps patch up the romance between Donovan and heroine Bernice.

A cowboy rides by night to catch the man who killed his brother.

Ace Beldon is in prison, but with his stolen bonds not recovered, Capt. Saunders has an idea. He sends Graham to prison and has him and Beldon break out. With Ranger Raymond assisting, they make their escape and get to the hangout run by Stone. But the plan starts to go awry when Sam overhears Graham talking with the Captain and reports back to Stone.

A sailor falls for a gangster's moll, leaves his wife and finds himself caught up in a life of crime.

In 1865, Captain Mark Smith of the Confederate Army leads a band of deserters to conquer Texas and rule it as a dictator. In one of his first actions, he captures and assumes the identity of Texas' new Finance Commissioner, Colonel Marcus Jeffries, after having the real man murdered. When a contingent of Texas Rangers enters the territory, Snead, one of Smith's men, leads them into an ambush by Smith's "troopers". The Rangers are apparently wiped out, although one injured survivor is left. The survivor, nursed back to health by Tonto, swears to avenge the massacre and defeat "Colonel Jeffries" and his men.

Burgess and Greeley are rustling horses and shooting Indians. When they kill Manual they frame Lieutenant Allister. His older brother John now attempts to defend him at his murder trial.