Ryan Kristoff, once a decorated naval captain must fight his past and inner demons to save his family from the "dormant" Mount Diablo. His estranged wife, a distinguished geologist, realizes that the fabled Diablo is about to erupt. She embarks on a mission to convince the local authorities to evacuate the city.

Immensely successful Professor Jonathan Caine has come out with a new book about his favorite subject, ants. He is known and respected all over the world but to his beautiful daughter, radio personality, Audrey Caine, he is an absentee parent. Nevertheless, Caine tries to heal the break between him and his daughter only to be called away to give another lecture on ants to a secretive multi-national corporation, Niles Industries, hidden in the Colorado wilderness. Meanwhile, his daughter, Audrey, is worried more than she’d like to admit. But when a giant ant escapes so does Caine. The giant ant sends out a sonic signal that travels across the four corners of the world and suddenly giant ants are appearing everywhere!

Two college roommates venture out to identify a fellow student, who is most likely to commit suicide as it will help them pass the semester.