A police raid in Detroit in 1967 results in one of the largest citizens' uprisings in the history of the United States.

Four sisters come of age in America in the aftermath of the Civil War.

After convincing his friends to perform in their drag outfits at a night club owned by a very homophobic businessman, things go awry when their performance is stopped suddenly by a wardrobe malfunction and their true identities are revealed, putting all their lives in instant peril.

A mosaic of characters struggle with addiction and love on the streets of Boston during the height of the fentanyl epidemic