What happens when normal people find they need to kill, in order to survive? This is the story of such a group of people, suddenly turned into vampires, and carving a path of blood and mayhem throughout New York City. Slowly, they lose their grip on reality, and turn into an army of anti-social, psychopathic misfits; and surely, they turn on each other.

In an imagined reality where zombies coexist with ordinary mortal folk, the undead are considered second-class citizens. Angela finds this out the hard way when she's shot by her boyfriend and must learn to adjust to her new zombie lifestyle. She tempers her hunger for human flesh with Zombies Anonymous meetings and tries to pass for living in the mortal world.

Scarlet is a single, workaholic Los Angeles matchmaker with no love life. Scarlet's mother is constantly trying to fix her up, to Scarlet's chagrin. Everything changes when homeless actress Sabrina crashes into her car, and into her life.