When lively lounge singer Deloris sees her mobster beau commit murder, she is relocated for her protection. Set up in the guise of a nun in a California convent, she proceeds to upend the quiet lives of the resident sisters.

Cookie is born, producing unmitigated joy in the Bumstead household. Adding to the chaos a new baby always creates is the appearance of Hans Conried as a cynical author who becomes caught up in the Bumstead lifestyle.

Miss Dove is a prim New England school teacher who is treasured by her students in the small town of Liberty Hill. When she falls ill, a kindly doctor, who is a former student of Miss Dove's, comes to her aid. As many of her pupils, present and past, come to see her in the hospital, they reveal how Miss Dove has greatly impacted their lives over the years. These visitors include a police officer, a playwright, a banker, a convict, and an unmarried mother.

A substance-addicted actress tries to look on the bright side even as she's forced to move back in with her mother to avoid unemployment.

Deloris Van Cartier is again asked to don the nun's habit to help a run-down Catholic school, presided over by Mother Superior. And if trying to reach out to a class full of uninterested students wasn't bad enough, the sisters discover that the school is due to be closed by the unscrupulous chief of a local authority.

An acerbic critic wreaks havoc when a hip injury forces him to move in indefinitely with a Midwestern family.

A woman suffers a nervous breakdown and an oppressive mother before being freed by the love of a man she meets on a cruise.

Stanley Ford leads an idyllic bachelor life. He is a nationally syndicated cartoonist whose Bash Brannigan series provides him with a luxury townhouse and a full-time valet, Charles. When he wakes up the morning after the night before - he had attended a friend's stag party - he finds that he is married to the very beautiful woman who popped out of the cake - and who doesn't speak a word of English. Despite his initial protestations, he comes to like married life and even changes his cartoon character from a super spy to a somewhat harried husband.

Bud and Lou are the owners of the amusement park Kiddieland. Bud, a compulsive gambler, gets in trouble with the mob, and Lou finds himself struggling to keep his adopted children. When Bud is forced to make a shady deal, Lou tries to arrange a deal with the DA, but winds up framed for murder.

Two talented song-and-dance men team up after the war to become one of the hottest acts in show business. In time they befriend and become romantically involved with the beautiful Haynes sisters who comprise a sister act.