A white dropout struggles to become a cartoonist and filmmaker, drawing inspiration from the harsh, gritty world around him. Still sharing his rundown apartment with his middle-aged parents, an oafish slob of an Italian father and a ditzy nutcase of a Jewish mother, he's ridiculed and looked down upon by his friends, hypocrites who run with violent gangs and the Italian Mafia, and a shallow Black girl who makes her living downtown with the pimps and pushers. The cartoonist gets a chance to pitch a film idea to a movie mogul, but the story proves too outrageous: a far-future Earth, depleted by war and pollution, where a mutant antihero challenges and kills God.

In 1953 Brooklyn, charismatic hood and The Stompers leader Vinnie Genzianna, his friend and second-in-command Crazy Shapiro, and their respective girlfriends Roz and Eva get wrapped up in an escalating conflict with the rival Black gang, The Chaplains, lead by Boogaloo Jones.