Estefanía, an 8 year old girl, refuses to accept the changes that her sister's illness causes in the family. Without understanding the disease, she thinks they have abandoned her.

As a child, Lucas falls in love with Ana. His story is truncated: she moves away and he loses track of her. Today Lucas does crossword puzzles and has almost zero love-sexual life. Meanwhile, his friend Santiago has a blind date with Verónica that ends after a few seconds. Verónica's neighbor is in a secret and quite toxic relationship.

Pablo, professor at the University of Buenos Aires, has an affair with Luciana, one of his students. Natalia, another professor at the University of Buenos Aires starts an affair with her student Gonzalo. Two stories, as two sides of the same coin.