When 24 year old apiring actor Mathieu meets and falls for 39 year old Jean-Marc who has just ended a seven year relationship, things are not all roses. In addition to their age difference there's the matter of Mathieu's five year old son from a previous marriage.

Skin and Bones gently introduce us to the world of anorexia and bulimia. The heroines of this moving film in which reality and fiction merge are called Annie, Andréanne, Hélène, Eisha. They have in common their youth and charm - as well as a terrible tendency to self-destruct.