A man-made virus, 'The Killing Strain'-- an out-of-control swine flu-- turns infected humans into raging monsters. As it rapidly spreads, a group of uninfected survivors must make life-or-death decisions before the U.S. military firebombs the area in a desperate attempt contain the contagion. The survivors are unaware that the virus has already reached their group-- by infecting one of them-- and now the merciless metamorphic process has begun.

Father Gabriel, a charismatic, man of God, undergoes a critical test of his faithfulness when he is reunited after 20 years with the woman he loved. Now a religious sister, she finds herself drawn to the mystical boxing priest who beyond being a dynamic leader in the community also heals the sick and performs miracles. When the two religious' passionate romance becomes uncontainable, they encounter a character from their past that will force Father Gabriel to choose between God's will and his will.

A group of survivors from all walks of the apocalypse – an idiotic Sheriff with definite coma-induced brain damage, his hardass son and a hobo with only a crossbow to stave off the walking dead, four squabbling friends forced to survive this zombieland together, and a lonely zombie who just needs love to fully regain his warm body – leave their once-safe mall hideout in search of the rumored Safe Haven Ranch, a refuge untouched by the zombie virus that has ravaged humanity.