In a world in which Great Britain has become a fascist state, a masked vigilante known only as “V” conducts guerrilla warfare against the oppressive British government. When V rescues a young woman from the secret police, he finds in her an ally with whom he can continue his fight to free the people of Britain.

Father and son coroners receive a mysterious unidentified corpse with no apparent cause of death. As they attempt to examine the "Jane Doe," they discover increasingly bizarre clues that hold the key to her terrifying secrets.