Although barely 30, Claire believes she is showing the first symptoms of Alzheimer's disease, a condition from which her mother has recently died. Her sister, Nathalie, is certain that her memory loss, caused by a lightning strike, is temporary. In the clinic where she is being treated, Claire is attracted to Philippe, a man who is still traumatized after a car accident in which his wife and child were both killed. In spite of their personal tragedies, Claire and Philippe fall in love. When Philippe recovers, Claire moves into his home. Then Claire's condition takes a turn for the worse.

Rue du retrait is a film which is quite unique to René Féret for various reasons.Firstly,it is a film which he shot in his own area,near his own house.Rue de retrait is the name of the street in 20th arrondissement in Paris where Mr.Féret stays.So in a way the location afforded a lot of familiarity in terms of location to the cinéaste. Secondly,the making of this film will always remain a miracle of sorts for René Féret as no big production house was willing to finance such a brave,absolutely uncommon film in France.So this film was finally made due to René Féret's personal intervention and highly individual efforts. Its visual style was applauded by a great French filmmaker named Bertrand Tavernier who has long been one of René Féret's admirers.