Franti, an organ grinder of the poor districts of New York, has a daughter, Isola, who sings to his street piano's accompaniment.

William Baldwin, ruined in business by his partner, John Blaisdell, implores Blaisdell's aid, and receives in answer a five-dollar bill across the face of which is written, "Spend this for a gun and use it on yourself."

On the lam from the New York Police because of a false murder charge, playboy Brooke Travers escapes to a Central American banana republic.

A European Ruler falls in love with an American.

When Princess Marie of the Balkan kingdom of Viatavia falls in love with Captain Rudi of the King's Guards, her father quickly arranges her marriage with the king of a neighboring country. Although Marie and Rudi are secretly wed by a Gypsy, the duke ignores the marriage and exiles Rudi. When a child is born to Marie, she declares to the king that it is Rudi's and is thereafter banished to a convent; however, Rudi returns and helps Marie retrieve her child from the palace, and they find happiness in another land.

While his daughter, Consuelo, is visiting the United States, Emanuel García, the Mayor of Alcorta in the Argentine, arranges for her marriage to Juan Martin, in return for Martin's financial assistance. On her return, Consuelo, who is in love with Philip Sears, an American engineer working in Argentina, refuses Juan but gives no reason. Juan is furious with outraged pride and soon kills Rafael Cornejo, the son of a senator, when he flirts with Consuelo.

Old Silas Blackburn, a wealthy recluse, lives alone with his butler and his ward Katherine. One night, Katherine discovers Silas murdered in the room where three generations of Blackburns have mysteriously died. Silas' grandson Robert, whom Katherine loves, comes to visit the next day, suffering from amnesia.

The disgrace and suicide of her father drives Eleanore Marston from her comfortable existence into a life as a department store clerk in New York. There she meets wealthy Powers Fiske, who offers her a life of luxury if she will consent to an operation on her brain which would deprive her of her memory.

Madame Vervier, a sophisticated woman, sends her daughter Alix to live with Owen Bradley's parents in London.

When a couple of scammers hold young Alice Faulkner against her will to discover the whereabouts of letters whose dissemination could cause a scandal affecting the royal family, Sherlock Holmes decides to take over the case. (Considered lost, a copy was found in 2014, in the vaults of the Cinémathèque Française.)