In 1990s Palermo, Pino Puglisi is a priest from the neglected Brancaccio neighborhood dedicated in helping kids to get off the streets and creating an embracing place of hope and solidarity in his church, which means trouble for the local Mafia. He continues his solitary fight until the bitter end.

In late 19th-century Sicily, the noble Uzeda family—whose lineage dates back to the ancient viceroys that ruled those lands—fights to preserve its waning power in the face of the newly unified Italian regime.