After her husband is arrested for looting, Lisette struggles for independence while dealing with her transgender sibling, her critical mother-in-law and assorted neighborhood eccentrics.

A New York schoolteacher experiences a midlife crisis when, in quick succession, her husband leaves, her adoptive mother dies, and her biological mother, an eccentric talk show host, materializes and turns her life upside down as she begins a courtship with the father of one of her students.

Ramón Iglesia, the head of a Puerto Rican family living in Long Island, encounters difficulties fulfilling his dream of moving back to Puerto Rico. Portrays many of the hardships faced by Puerto Ricans and other Hispanics in the United States, including confrontation among family members as traditional Hispanic values conflict with American values.

The lives of diverse characters in each of New York City's five boroughs overlap.

When his partner is killed, tough Irish detective Eddie Ryan vows to avenge the death, whatever the cost. As he begins unraveling clues, his behavior becomes so outrageous that he's obliged to turn in his badge, but the experience only emboldens him. Ryan eventually learns that his partner was caught up in a Puerto Rican gun-running scheme masterminded by a crook named Sweet Willie, who wants to foment revolutionary war.

Andrea Crawford, an important business woman, risks everything to save a kid from the life of crime.

Bored with day-to-day life in New York City and neglected by her husband, a young wife and mother slips into increasingly outrageous fantasies: her mother breaking into the apartment, an explorer's demonstration of tribal fertility music at a party causing strange transformations, and joining terrorists to plant explosives in the Statue of Liberty.

The rise and fall of salsa singer, Héctor Lavoe (1946-1993), as told from the perspective of his wife Puchi, who looks back from 2002.

Marie is a vampire with a thirst for bad guys. When she fails to properly dispose of one of her victims, a violent mob boss, she bites off more than she can chew and faces a new, immortal danger.