Detlev, a single insurance clerk in his 30s, is kept dependent by his loving and caring mother and loses his girlfriend Karin as a result. Grief and an alcoholic chance acquaintance prompt him to place an ad for marriage. Detlev gets caught up in a whirlwind of friendships and love affairs: with the caring widow Karin; the well-to-do hair salon owner Ute Schöbel; the cultural editor Norma Goldbach, the photo reporter Kerstin and the student Andrea Binz. Detlev, who initially proves himself as a friend and advisor, but also as a lover, becomes increasingly self-confident. He is also successful in his work and finally emancipates himself from his mother. Although he loses "his" women in a turbulent odyssey, Detlev has transformed himself from a mama's boy into a thoroughly acceptable man.

The plot takes viewers to various places in Europe, including Prague, Erfurt, Frankfurt/Main and even Tenerife. And the title "The Blonde Geisha" turned out to be a nickname for the film's heroine, who had once been called that by her school friend Andreas. At the time, there was more than a hint of romance between the two, but then they lost sight of each other. Now, all of a sudden, a reunion in Prague! This would be a chance for Erika and Andraes to start afresh, but the two are not alone in the Czechoslovakian capital, as if on an island. Instead, the businesswoman from West Germany and the research engineer from East Germany find themselves in the sights of shady people who do not shy away from crime in order to achieve their goals, and so the two main protagonists find themselves in increasingly dangerous situations.