Charlie Chan is an agent of the US government working in Washington DC and he is assigned to investigate the murder of the inventor of a highly advanced torpedo. Aiding Chan is his overeager but dull-witted son Tommy and his daughter Iris.

Shortly before Pearl Harbor, American opportunist Jones and partner Johnny are in China to sell oil to the invading Japanese army. Cynical about the sufferings of the Chinese, Jones meets compassionate teacher Carolyn Grant while travelling cross-country to Shanghai. Sparks fly between these strong-willed characters, neither budging an inch. But when Jones witnesses a Japanese atrocity, his feelings toward his customers (and Carolyn) begin to change...

In this 13th entry to the Dr. Kildare series, the medical staff of Blair General hospital are challenged with further dilemmas, not the least of which includes a prison inmate who Dr. Gillespie believes belongs instead in an insane asylum.