The PFL 8 mixed martial arts event for the 2021 season of the Professional Fighters League was held on August 19, 2021. This was the second event for of the playoffs with the Heavyweight and Women's Lightweight divisions competing. This event aired on ESPN, with the prelims on ESPN+. Kayla Harrison, the only two-time Olympic gold medalist in judo in the history of the United States, entered her second PFL playoffs unbeaten in 10 pro bouts. She faced Genah Fabian who held a 4-1 record and had won both of her PFL regular season bouts against Julija Pajic and Laura Sanchez to advance to the playoffs.

The PFL 6 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 25, 2021. This was the third regular season event of the tournament and included fights in the Heavyweight and women's Lightweight divisions. This event will aire on ESPN2, with the prelims on ESPN+. The event was headlined by Two-time Olympic gold medalist Kayla Harrison and Cindy Dandois.

The event was headlined by a heavyweight bout, contested by the former UFC Heavyweight champion Fabrício Werdum and Renan Ferreira. In the co-main event, the 2019 PFL Lightweight champion Kayla Harrison fought Mariana Morais.

Katja Kankaanpaa "Killer Bunny" (70%) 19-8 (30%) DeAnna Bennett "The Argentine Assassin" Tonya Evinger "Triple Threat" (73%) 19-7 (27%) Pannie Kianzad Rachael Ostovich (23%) 5-17 (77%) Andrea Lee "KGB" Roxanne Modafferi "The Happy Warrior" (56%) 10-8 (44%) Mariana Morais Jinh Yu (59%) 10-7 (41%) Liz McCarthy "Lightning" Aspen Ladd (63%) 10-6 (38%) Amanda Bobby Cooper Cindy Dandois (36%) 5-9 (64%) Megan Anderson Jamie Moyle (58%) 7-5 (42%) Sharon Jacobsen JJ Aldrich (78%) 7-2 (22%) Daniela Kortmann Rachel Wiley (43%) 3-4 (57%) Felicia Spencer

Invicta FC 27: Kaufman vs. Kianzad was a mixed martial arts event headlined by veteran Sarah Kaufman returning to Invicta against Pannie Kianzad. On December 6, Invicta announced Kaufman had been signed to return for a headline bout. A strawweight bout between Mallory Martin and Tiffany Masters was made after being originally scheduled for Invicta FC 24.