The first part of this documentary deals with the Portuguese neurologist António Egas Moniz, Nobel Prize for Medicine in 1949, one of the first surgeons to apply the technique called lobotomy for the treatment of schizophrenia. The second part deals with the everyday life of people with schizophrenia today: behavior and relationships, and treatment for the disease.

Lucas Santos, named El Santo is petty thief going continuously in and out of jail. Tired of small thefts, he aims to strike a blow that makes him famous and become the star of all media. His wife Lucia, a comprehensive and sweet woman, while awaiting the return of her husband, works as a stripper at a nightclub. Finally, Lucas gathers a band of petty thieves and decides to steal, from the National Museum of Art Reina Sofía, its most valuable painting: Picasso's Guernica.