Living among boys is easy, each of them with their own mess, unregimented lifestyle, and unique "method of study." The male universe in which they live, however, is about to be invaded by women. Giorgia is independent and receives little attention from her parents; Francesca is in a doomed relationship with an older professor, while Emma wants to be a famous performer. In this new mixed arrangement house, each character finds their place as they establish a confusing, but fun and tumultuous extended family - a family which none of them has ever truly had.

A quartet of stories unfold across four holidays as family members, friends and colleagues face hard decisions, career setbacks and life-changing events.

A portrait of the flaws and peculiarities of four type of girls living in different districts of Rome.