Brandon, a thirty-something man living in New York, eludes intimacy with women but feeds his deepest desires with a compulsive addiction to sex. When his younger sister temporarily moves into his apartment, stirring up bitter memories of their shared painful past, Brandon's life, like his fragile mind, gets out of control.

When a frightening wave of violence sweeps through New York City, troubled cop Sarchie fails to find a rational explanation for the bizarre crimes. However, his eyes are opened to a frightening alternate reality when renegade Jesuit priest Mendoza convinces him that demonic possession may be to blame for the gruesome murders. Together, they wage a valiant supernatural struggle to rid the city of an otherworldly evil.