When the pictures from Bergamo in Italy go around the world in spring 2020, even non-medical people know what the word pandemic means. The previously unknown Coronavirus is spreading rapidly across the planet. Four days later, exit and contact restrictions also apply in Germany. Since then, the life of the Konstanz intensive care physician Dr. Carolin Mellau and her family on their heads. The female doctor becomes a member of the crisis team and is on duty around the clock to prepare the clinic for the impending emergency. As an anesthesiologist intubating those infected with COVID-19, she herself carries a high risk of infection. Meanwhile, her husband Stefan has to cancel his concerts as a musician, is no longer allowed to teach his music students and is suddenly sitting at home without an income. Teenage daughter Luzy is not allowed to see her Swiss boyfriend because the border is closed. She and brother Tim cannot go to school. But the worst case for the family is yet to come.

Johannes Friederich Selinger is in his mid-30s and has nothing to show for his life apart from failure. Only the dream of becoming famous keeps him on track. He is now prepared to take drastic measures to achieve this. Together with two friends, he sets off for the USA, where he wants to make a movie like no other before, starring himself and his new identity John Frederik Salinger: he wants to sacrifice one body part after another in front of the camera in order to win the admiration of the masses.

When the green box is being delivered, organic farmer Helena (Julia Koschitz) stumbles over the dashing David (Vladimir Burlakov), a law student and starts an affair with him. In fourteen years of marriage, Helena and Thomas (Marcus Mittermeier) have transformed the infatuation of the first years into a dependable, constant affection. But her husband feels that she is keeping something from him. He spies on her, challenges David, and kills him.Later there is silence between the spouses. Then the detective is at the door because the review of David's cell phone connections leads to Helena. And then she discovers what Thomas has done. Only now there is a debate. They want to save the marriage and cover up the murder.

Bella Sommer lives in Mallorca and works in the dental practice of Dr. med. Jonas Berger, her great love. The problem is, your boss does not know that his loyal receptionist secretly idolizes him. Rather, he punishes her with demonstrative disregard when it comes to the private.

The widower Danyal worries about his adult daughter Jila, even though the doctor has long been on her own feet. When the man in his mid-fifties can't reach her by phone, he rushes from Kitzingen in Franconia to Berlin with two friends. The career lawyer Markus and the entertainer Tobi, also loving fathers with adult daughters in the capital, would like to combine the friendship service with the opportunity to visit their offspring. However, as soon as they arrive, the three realize that they know very little about the lives of the young women. Jila doesn't want to talk to Danyal because she believes he is responsible for the failure of several relationships, the unsuccessful actress Tilda is burdened by her father's excessive career expectations and Hanna confronts the complacent judge Markus about a secret marriage for legally questionable reasons. The three fathers' short trip develops a dynamic of its own that also pushes the daughters to their limits.

Eva Simon is actually a woman who can not be shaken by anything: Together with the family of her son Theo, she lives contentedly on a former farm in the picturesque Rheingau, where she practically does the housework on her own and takes care of her grandchildren Lilli and Nico, while Theo and his wife Marlene pursue their professions. But that the young, fun-loving photographer Jonathan Wolf is now moving into a side building of the courtyard and setting up his studio precisely where Eva once ran her beloved cabaret - that's too much for the self-confident woman in her mid-fifties.

On a class trip to the GDR in 1986, Annette flirted with the East German Michael. Today she is working on reconstructing shredded Stasi files and comes across a photo of him. Annette finds Michael and their love flares up again. Not just out of jealousy, Annette's boyfriend Johannes investigates whether her rival was a Stasi victim or possibly a perpetrator...

The death of a young woman who offered online sex and is murdered by a stranger, with her death being retrieved on the internet, calls the homicide squad into action. Not an easy task for the young detective, who has a relationship with his superior but feels magically attracted to one of the virtual love servants.

Heike and Stefan have been a couple for many years and have a big goal together: to sail around the world on their own catamaran. One day the time has come, they leave their home in northern Germany behind and set sail. Their happiness seems perfect when they find a beautiful paradise on the island of Nuku Hiva in the South Pacific. Here, their dream of unrestricted freedom in harmony with nature is fulfilled. Their happiness comes to an abrupt end when Stefan fails to return to the boat after an excursion with a local. A never-ending nightmare begins for Heike.