A film editor receives a proposal to edit a new film without knowing that he is going to become so obsessed with the project that he will do whatever it takes to save the protagonist from her death in the story.

Lorena tries to rebuild her life while her husband, a manipulative Italian-Argentinean, slowly and subtly locks her up in a psychological prison from which she must escape.

A theater group made up of various actresses and a male director are rehearsing a play when several cases of invisible abuse and homophobia begin to occur. The women begin to talk to each other and discover that they all have a painful story to tell.

In the thickness of the mountains, in an isolated community led by a preacher known as El Señor, a presumed new Messiah is brought, unleashing a wave of violence and pain.

Leading Ladies reflects how guilt affects us in different ways based on our perspective or memories. A welcome dinner is the excuse to discover that we always keep a secret from who know us the best. Five points of view that show us that each of these five girls tries, as best they can, to lead their own lives. Some lies have been saved for years, other where hidden for months… But many of them will come to light during this special meeting.