Vera is a young woman trying to cope with her life, plagued by a violent relationship, when she suddenly receives terrible news: her best friend has been murdered.

On her birthday, Mery receives the worst news: her husband died in a confusing road accident. Meanwhile, Román, the boyfriend of Mery's teenage daughter, Celina, was involved in the accident. The processes of grief and how to deal with guilt as a teenager come together to tell the story of survival in "The Last Birthday."

Gustavo Alsina is a young writer who arrives at his aunt and uncle's house to find inspiration for a new novel. There, he meets Marina, a psychiatric patient twenty years his senior who escaped from the clinic run by Rubén Alsina, his uncle. Marina believes she is the character in a book she carries like her Bible, and her goal is to find the God who wrote her destiny before the final chapter arrives. The death of a nurse at the clinic is key to this film. Romance and suspense come together to tell this story.

After midnight, Ángeles and her son Miguel knock on the door of Mercedes's house. The house is located in the mountains a few kilometers from the highway. Mercedes's life is neglected due to her advanced age. Ángeles' humanity, Mercedes's hope of one day seeing her children again, and the secret Miguel keeps make this film a story that will touch the heart.