An ambitious anthology film featuring segments directed by over two dozen of the world's leading talents in contemporary genre film. Inspired by children's educational ABC books, the film comprises 26 individual chapters, each helmed by a different director assigned a letter of the alphabet. The directors were then given free reign in choosing a word to create a story involving death.

When the mysterious woman in the room next door disappears, a debonair 70-year-old ex-spy living in a luxury hotel on the Côte d'Azur is confronted by the demons and darlings of a lurid past in which moviemaking, memories and madness collide.

Returning home from a business trip to discover his wife missing, a man delves deeper and deeper into a surreal kaleidoscope of half-baked leads, seduction, deceit, and murder.