The mega-corporate Daedalus Group is under attack by a small group of activists known as the Ghost of Icarus. While taking care of some of the victims of the bombing, Black Jack encounters Dr. Kiriko, also known as Death Incarnate, who just like him, asks his patients huge sums of money but instead of saving them, he offers them a painless death. When the activist group requests both doctors’ collaboration, Black Jack finds himself caught in a spiral of life, death and treason while trying to save his patients' lives and avoid the breaking of a biological war that could destroy humanity.

I'm, Asahina Mirai! Everyone, do you know about the "Wishing Stone"? It's a powerful stone that can grant any wish you want! Today is the day we're celebrating its revival, a huge magic festival that only occurs once a century♪ Together with Liko and Ha-chan, I wish upon this "Wishing Stone", but believe or not, it chose Mofurun's wish! This is truly exciting!! However...a mysterious bear・Dark Matter suddenly appears, and takes Mofurun with him!! I have to definitely save Mofurun! Even when we're separated, the wishes of all of us can bring about miracles!! Well that is what I thought, what~~~!! Mofurun became a Pretty Cure~!?

The year is 2148. Two years have passed since the world was defended from the mysterious Festum, leaving the world in peace. Soushi promised Kazuki that he would one day return to Tatsumiya Island but instead he still keeps himself hidden, living his life in the peace that he created. But one day a mysterious ship arrives at Tatsumiya Island... a ship with nobody but a single sleeping girl on board. The peace isn't going to last as long as everyone might hope...