The PFL 10 mixed martial arts event for the 2021 season of the Professional Fighters League was held on October 27, 2021. This was the finale of the playoffs for all divisions, with the winners getting $1 million cash prize. Kayla Harrison, a two-time Olympic gold medalist in judo and is seeking her second PFL championship, headlined the PFL event opposite Taylor Guardado, who emerged as an unexpected finalist in 2021. The event also featured five other finals matchups, with the winner of each weight class taking home PFL's trademark $1 million prize.

The PFL 4 mixed martial arts event for the 2019 season of the Professional Fighters League was held on July 11, 2019, at the Ocean Resort Casino in Atlantic City, New Jersey. This was the fourth regular season event of 2019 and include fights in the welterweight and women's lightweight divisions.

The PFL 7 mixed martial arts event for the 2019 season of the Professional Fighters League was held on October 11, 2019, at the Mandalay Bay Events Center in Las Vegas, Nevada. Kayla Harrison was initially scheduled to face Genah Fabian at this event. However, Fabian missed weight and was replaced by Bobbi-Jo Dalziel.

The PFL 5 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 17, 2021. This was the second regular season event of the tournament and included fights in the Welterweight and Light heavyweight divisions. The event was headlined by a welterweight clash between the former UFC title contender and Bellator welterweight champion Rory MacDonald and the former UFC veteran Gleison Tibau.

PFL 4: 2023 Regular Season was a mixed martial arts event that took place on Friday, June 23, 2023 at the Overtime Elite Arena in Atlanta, Georgia.

PFL 9 was a mixed martial arts event produced by the Professional Fighters League that took place on August 23, 2023, at The Theater at Madison Square Garden in New York City, New York, United States. The event was headlined by a lightweight playoff bout between Clay Collard facing off against Shane Burgos in an attempt to reach the lightweight final.

Week 6 of the regular season happens tonight (Jul 1) in Atlanta, GA and features a main event between two-time PFL women’s lightweight champion Kayla Harrison and women’s MMA pioneer Kaitlin Young, who is filling in for the injured Julia Budd. The co-main event pits former UFC welterweight title challenger and ex-Bellator champion Rory MacDonald against Sadibou Sy.

The PFL 7 mixed martial arts event for the 2021 season of the Professional Fighters League was held on August 13, 2021. This was the start of the playoffs for the Welterweight and Lightweight divisions. This event aired on ESPN2, with the prelims on ESPN+.

The PFL 10 mixed martial arts event for the 2022 season of the Professional Fighters League will be held on November 25, 2022, at the Hulu Theater in New York City, New York, United States. This will be the finale of the playoffs for all divisions, with the winners getting $1 million cash prize. The event also will also mark the organization's first pay-per-view card, being available on ESPN+ PPV.

PFL #6 was a mixed martial arts event for the 2018 season of the Professional Fighters League that was held on August 16, 2018 at the Ocean Resort Casino, in Atlantic City, New Jersey, United States.