A successful Texas gynecologist finds himself amid a bevy of women and their problems – his wife’s breakdown, his daughter's fake marriage, his other daughter’s conspiracy theories, and his secretary’s crush. Craving time for himself, he finds solace in a kind outsider.

Novalee Nation is a 17-year-old Tennessee transient who has to grow up in a hurry when she's left pregnant and abandoned by her boyfriend on a roadside, and takes refuge in the friendly aisles of Wal-Mart. Eventually, some eccentric but kindly strangers 'adopt' Novalee and her infant daughter, helping them buck the odds and build a new life.

Nick's plan to let fate bring his wife to him must be altered because he must replace his father as Santa Claus on December 26. Ernst, the right-hand man to several generations of Santas, generates a list of potential mates. Nick dutifully sets off to meet them, but fate may have a candidate after all.