A disparate group of people meet as passengers on a superspeed train crossing the U.S. Aboard are a seductive blackmailer and the stage director he intends to frame, a woman chasing her husband who is running away with the blackmail victim, and the stage director's feisty leading lady.

A chemical manufacturer is killed just after asking detective James Wong to help him. So detective Wong decides to investigate this as well as two subsequent murders.

Pacific pearl diver Duke Slade escapes angry natives by joining a whaler whose dying captain persuades him to marry his daughter who is already being wooed by the first mate.

A temperamental Broadway producer trains an untutored actress, but when she becomes a star, she proves a match for him.

Assistant District Attorney Jeffery Powell has just sent an innocent man to prison for the murder of a gambler. Powell is in love with, Marion Courtney, but he's unaware that Marion is the sister of the innocent man he sent to prison. Marion gets herself committed to a women's prison to get proof from inmate, Evelyn 'Duchess' Thane, that her brother is innocent. Powell learns of Marion's plight and believes she's in love with the man he sent to prison.

Bootlegger/cafe owner, Johnny Franks recruits crude working man Scorpio to join his gang, masterminded by crooked criminal defense lawyer Newton. Scorpio eventually takes over Frank's operation, beats a rival gang, becomes wealthy, and dominates the city for several years until a secret group of six masked businessmen have him prosecuted and sent to the electric chair.

Having briefly abandoned his standard "Nevada Jack McKenzie" characterization in Flame of the West, cowboy star Johnny Mack Brown was back as Nevada Jack in Monogram's The Lost Trail. Vowing to bring in a gang of stagecoach outlaws, Nevada redoubles his efforts when he learns that the owner of the stagecoach line is pretty Jane Burns (Jennifer Holt).

Roy and Gabby fight bad guys to save the town of Deadwood.

It's cattlemen versus sheepmen and Trigger Gargan appears to be the leader of the gang causing the trouble. But unknown to Ranger Tex Lawrence, the respected town citizen Barrow is the boss and is tipping off the gang as to the Ranger's activities.

Tex is after the gang that robbed a train of a gold shipment. He suspects Dorman is the culprit and is hiding their gold at his mine. When Stubby sees Dorman's henchman Stark cash in some gold nuggets, Tex tricks Dorman into moving the gold. He hopes to round them up with the help of the posse and the local Boy Scout Troop.