A married woman has an affair with a suicidal lover while caring for her husband's sick relatives.

It Seems to Hang On is based on the true story of the serial killers Alton Coleman and Debra Brown, a young Black couple who cut a violent path beginning in the summer of 1984 through the American Midwest (Ohio, Kentucky, Michigan, Indiana, Illinois and Wisconsin). The dialogue spoken in the film is inspired and based on lyrics from the American soul duo (and couple) Ashford and Simpson's 1979 hit song "It Seems to Hang On".

While training at the gym, 11-year-old tomboy Toni becomes entranced with a dance troupe. As she struggles to fit in, she finds herself caught up in danger as the group begins to suffer from fainting spells and other violent fits.