Carny con artist and snake-oil salesman Eustace McGargle tries to stay one step ahead of the sheriff but is completely devoted to his beloved daughter Poppy.

Jury foreman Edward Weldon's questioning leads to the death sentence for Ethel Saxon. His daughter Stella claims to have killed her lover, the gangster Garboni, just as Saxon was to sit in the electric chair.

The Bellows family causes comic confusion on an ocean liner, with time out for radio-style musical acts.

Big Steve Halloway, gambler and proprietor of New York's Horseshoe Cabaret, is in desperate need of money. He arranges for his fellow bookies, especially Sorrowful Jones, to each pay him $1,000 for his racehorse, Dream Prince, to lose. With all bets being placed at the window, Sorrowful encounters a gambler, having lost $500, wanting to place his bet but unable to come up with $20. Instead, he places his little girl, Marthy Jane, as security, or in bookie's terms a "marker". "Marky", as she comes to be known, winds up under the care of Sorrowful Jones and his lady friend, singer Bangles Carson.

In flashback, fifty years after inventing the light bulb, an 82-year-old Edison tells his story starting at age twenty-two with his arrival in New York. He's on his way with the invention of an early form of the stock market ticker.

One of the last bills signed by President Lincoln authorizes pushing the Union Pacific Railroad across the wilderness to California. But financial opportunist Asa Barrows hopes to profit from obstructing it. Chief troubleshooter Jeff Butler has his hands full fighting Barrows' agent, gambler Sid Campeau; Campeau's partner Dick Allen is Jeff's war buddy and rival suitor for engineer's daughter Molly Monahan. Who will survive the effort to push the railroad through at any cost?

The Florida Keys in 1840, where the implacable hurricanes of the Caribbean scream, where the salvagers of Key West, like the intrepid and beautiful Loxi Claiborne and her crew, reap, aboard frail schooners, the harvest of the wild wind, facing the shark teeth of the reefs to rescue the sailors and the cargo from the shipwrecks caused by the scavengers of the sea.

A police inspector 'solves' a crime that, in fact, may not have occurred at all.

Texas Ranger Dusty Rivers ("Isn't that a contradiction in terms?", another character asks him) travels to Canada in the 1880s in search of Jacques Corbeau, who is wanted for murder. He wanders into the midst of the Riel Rebellion, in which Métis (people of French and Native heritage) and Natives want a separate nation. Dusty falls for nurse April Logan, who is also loved by Mountie Jim Brett. April's brother is involved with Courbeau's daughter Louvette, which leads to trouble during the battles between the rebels and the Mounties. Through it all Dusty is determined to bring Corbeau back to Texas (and April, too, if he can manage it.)

A café in Chicago, 1942. On a rainy night, veteran reporter Homer Howard tells an increasing audience the story of Roxie Hart and the crime she was judged for in 1927.