The movie revolves around a huge transnational drug trafficking transaction. Lei Zhanjun and Lei Zhansheng are twin brothers. The younger brother was involved in a local gang vendetta. He faked his death and had plastic surgery and escaped unscathed, taking away a huge amount of the gang's funds. The elder brother, who did not know the inside story, crossed national borders and chased the murderer thousands of miles away in order to find out the truth about his younger brother's "death". The younger brother, who had escaped, returned with a new face and identity in order to save his elder brother. Together with his elder brother, he desperately escaped under the double pursuit of the police and the underworld.

In Country A, Zhao Jian leads his Black Wolf Squad to escort cargo for General Cha Cai. They are ambushed by guerrillas. Zhao Jian captures the guerrilla leader Zhang Ling and learns that the Black Wolf Squad isn't transporting humanitarian supplies but materials for human experimentation conducted by Cha Cai for personal gain. Zhang Ling pleads for help from the Black Wolf Squad but is refused. On their way back, the squad stumbles upon the horrifying aftermath of the human experiments in the jungle. Overcome with sorrow, Zhao Jian decides to quit the Squad and join Zhang Ling to fight Cha Cai. Zhao Jian is backed by his teammates, who vow to wipe out Cha Cai's organization and avenge the dead.

Cha Jing, a fearless and just hero, confronts betrayal and the battle between good and evil. Once close comrades, Cha Jing, and Tony Gu grow apart, leading Tony to frame him during a critical mission.