Two brothers, Samuel and Rodrigo, live with their mother in a suburban town. One day the mother, who has mental health problems, disappears leaving nothing behind but a note. David Pablos is a young Mexican filmmaker, born in 1982. His first short film, El mundo al atardecer, was made in 2007. La canción de los niños muertos (2008) was his second short film; he presented his first feature-length film Una frontera, todas las fronteras (2010) at the Berlinale Talent Campus before coming to Venice with his second film, La vida despues, for the 70th Venice International Film Festival.

Angélica and José Luis have been married for thirty years and they have always lived at the same house; first with their son, Daniel, and now, by themselves. Their daily routine is threatened when José Luis loses a leg in a car accident. When they try to restructure their life, they realize their relation was already fractured and opt for silence. However, they begin a passionate search for all they have lost. José Luis takes refuge in a sexual fantasy about his young nurse, while Angélica tries to remain just as contained as she always has for so many years.

Verónica, a middle-aged highschool history teacher, leads a non eventful life: she has grownup children, grandchildren and a less than perfect marriage. This dynamic seems to be the only thing she can hold on to, as she battles a terminal illness. As she reluctantly accepts her fate, she meets Eva, an irreverent and misunderstood new student who unknowingly injects some life and enthusiasm back into her and provides her with the tools to deal with her destiny.