Two apathetic twentysomethings spend the night of Saturday deciding whether or not to go to a costume party. As time passes by, more friends, more drugs are added and everything ends in a small tragedy that will completely change the fate of the night.

Carmen Vidal is a private detective addicted to pizza, beer and marijuana who fights against a criminal senator to avenge the death of her best friend.

Andres and Elias get together one evening for their last summer joint. On his way home, Elias finds a hidden case containing 5 different types of drugs. The next morning, Elias calls Andres to catch up on his discovery. He tells him he wants to gather round with some friends to perform an experiment: each should take a different drug and see what happens. The experiment takes a sudden turn when Andres girlfriend calls him to say her grandma has died.

Ana is a twentysomething artist: she teaches art to kids, goes to parties, and tries to avoid running into her ex. A gallery owner invites her to put on her first solo show. As she scrambles to get it ready in time, she meets a new girl. Buenos F**cking Aires is a portrait of a generation immersed in the nightlife and contemporary art scene of Buenos Aires: a story about adulthood, friendship, miscommunication, and job insecurity.