Set in New York City, The Elegant Clockwork of the Universe chronicles the immediate days following a young woman, Mala Adou’s disappearance, and her boyfriend, Muhammad’s dogged drive to find her. Muhammad Masood is a middle school teacher whose life is turned upside down when he awakens one morning to find his lover, Mala Adou, of six years gone—leaving behind everything.

Two romantically involved government operatives Claire Stenwick and Ray Koval team up to manipulate a race between opposing corporations to corner the market on a medical innovation that will reap huge profits and allow them to lead an extravagant lifestyle together. They find themselves on opposing sides as corporate spies; however, as they each try to outdo the other, neither one can decide how far to trust the other in this high-stakes game of cat-and-mouse.

Spike Lee's take on the "Son of Sam" murders in New York City during the summer of 1977 centering on the residents of an Italian-American Northeast Bronx neighborhood who live in fear and distrust of one another.