Adam's plan to propose to Allie hits a snag when he must win over her skeptical dad and survive a wild family gathering. Little does this family know that a much bigger problem crashed down in the woods the night they arrived: a big, body-snatching, hive queen alien, and it’s looking for its perfect match. Soon enough, the alien will take the family members one by one. Adam will have to team up with Government Agent Owens to take down the alien, rescue his girlfriend, and save the rest of the world.

On May 21, 1990, roughly 1,000 activists and members of the AIDS Coalition to Unleash Power (ACT UP) marched on the Bethesda, Maryland campus of the National Institute of Health to protest the lack of available drugs to treat HIV/AIDS. Dr. Anthony Fauci, then director of the NIAID (the AIDS arm of the NIH), watches as the activists march around his building, demanding inclusion in his clinical research committees. Meanwhile, a young gay filmmaker captures the events of the protest while attempting to deliver a package to Fauci. As the demonstrations threaten to upend the scientists' work, both men are forced to reckon with the meaning of power and responsibility.