A prostitute is brutally killed by the road side by a maniancal killer. Nearby a horror film is being produced but the director is worried that the script is too passé for a modern audience and so he plans to include a séance scene - he hires a real medium to carry out a ceremony with the cast and crew to help inspire the script but she is attacked by an evil spirit. Meanwhile members of the cast are being picked off one by one and police detective Walter is desperate to stop his girlfriend, the lead actress Jennifer, becoming the next victim...

The master of Italian horror, Lucio Fulci, stars as... Lucio Fulci, a filmmaker with a reputation for gruesome horror films. His body of work has started to plague his mental state, and he is haunted by the grotesque set-pieces his mind has conjured up during his career. His psychiatrist, Egon Schwarz, uses a hypnotised Fulci as an avatar to carry out his own disturbed fantasies, in hopes of ruining the master’s reputation once and for all.

A murdered couple return from the beyond to care for their two young children, as well as seek revenge against their killer, accept their children's step parents, and try to prevent their house from being sold.