Ten years after the first American Pie movie, three new hapless virgins discover the Bible hidden in the school library at East Great Falls High. Unfortunately for them, the book is ruined, and with incomplete advice, the Bible leads them on a hilarious journey to lose their virginity.

When five friends head to the woods for a weekend of drug fueled madness their night soon descends into chaos when they pitch up next to the grave of a local missing child.

Rebecca and Michael decide to take a weekend getaway and drive into the isolated countryside They arrive at their cottage unscathed, but Rebecca can't help but feel like someone is watching.