Fearful that their star witness might be murdered, two attorneys hire a protector to bring him from Los Angeles to New York. Jesse Crowder (Fred Williamson) is a no-nonsense tough guy. He buddies up with the witness, an accountant, and they hit the road. Outwitting their foes means taking all manner of conveyance, including automobile, train, and airplane.

Two uneasy friends, a police officer and a TV talk show host, each pursue the mysterious "handcuff killer" with the aid of an artist who sees - and draws - the killer's crimes before they're committed.

Airline security specialist John Cutter, finally returning to the job after his wife's death, finds himself stuck on a flight being hijacked by notorious terrorist Charles Rane. Unfortunately for the terrorists, they're also stuck with him.