A small group of people board the commuter bus at its usual bus stop. After the bus is in motion, the passengers begin to realize something is wrong. The bus driver gases them to sleep. They awake to find themselves enroute to another planet.

Due to a chemical weapons experiment gone wrong, the entire Earth became afflicted with total color blindness. A scientist finds a formula to correct the eyes perception of color, but as he is about to release it to the world, sinister forces murder him and steal the formula. Or think they have. They didn't steal the main piece of the formula and will now stop at nothing to get it! Monochromia is a comedy of greed, corruption, greed and more greed.

Real life Mad Scientist "Dr. Drek" and his undead cheerleader assistant "Moaner" accidentally become Horror Host at a local television station.