Mishaps befall a new home owner located next door to an insane asylum.

The Wiggs family plan to celebrate Thanksgiving in their rundown shack with leftover stew, without Mr. Wiggs who wandered off long ago an has never been heard from. Do-gooder Miss Lucy brings them a real feast. Her boyfriend Bob arranges to take Wiggs' sick boy to a hospital. Their other boy makes some money peddling kindling and takes the family to a show. Mrs. Wiggs is called to the hopsital just in time to see her boy die. Her neighbor Miss Mazy wants to marry Mr. Stubbins who insists on tasting her cooking. Mrs. Wiggs sneaks her dishes past Stubbins who agrees to marriage. Mr. Wiggs appears suddenly, in tatters, with just the amount of money (twenty dollars) needed to save the family from foreclosure. Miss Lucy and Bob get married.

When her latest show closes, Pat O'Brien returns home. The stable owned by her fiancé, Dan Mallory, catches fire, and Pat helps save his prize horse, Lady Belle, who is blinded. Because of the fire, Pat and Dan have to put their wedding plans on hold, and Pat returns to the stage.

Mary Ainslie has been waiting 30 years for her fiancé, a sea captain, to return. She has kept a light burning in her window to guide him home. His son Carl, by another woman, arrives on vacation in the New England village where Mary lives. Mary is overcome by the resemblance between the young man and his father. The young man falls in love with Ruth, Mary's young comrade. On her deathbed, Mary wishes Carl and Ruth the romantic life that she did not live.

Frankie Kelly is the soda jerk and embryo scientist in Midvales only drugstore. Two murders and an attempted killing suddenly swing Midvale into national prominence. Frankie and his pal, Jefferson, become involved when a wounded gangster starts to tell them where $300,000 in stolen loot is hidden, but he is murdered before he can give them all of the information. The search is on.

A young fighter, Bill Hickey, achieves success through the help and support of his friends and, once he does, he gets a big case of 'swellhead.' And then he loses his friends, loses his girl-friend, loses his confidence and is all set-up to lose his title.

Charley has to marry quickly or he'll lose out on a job.

A young French soldier in World War I is overcome with guilt when he kills a German soldier who, like himself, is a musically gifted conscript, each having attended the same musical conservatory in France. The fact that the incident occurred in war does not assuage his guilt. He travels to Germany to meet the man's family.

When Polly Fisher, a circus aerialist, is hurt while performing, she is taken to the house of a nearby minister, John Hartley. As she recuperates, they fall in love with each other and secretly marry. But when the truth leaks out , John's congregation rebels at having a circus woman as their minister's wife, and he is fired. Polly decides to leave John in hopes of giving back to him the calling that means so much to him. But fate steps in and rearranges all plans.

Homer Crow, fired from his laboratory job at the Dunn-Wright Rubber Company, is sure that his formula for an indestructible rubber, called Durex, will be a success. Others are also, and Honer endures many obstacles, prat-falls and staged accidents while striving to protect his inventions.