This time the "amici" (friends) are just four: Necchi, Meandri, Mascetti and Sassaroli. Nevertheless they are older they still love to spend their time mainly organizing irresistible jokes to everyone in every kind of situation. Mascetti is hospitalized in a geriatric clinic. Of course the place become immediately the main stage for all their jokes. After some jokes they decided to place an ultimate incredible and farcical joke to the clinic guests.

The action takes place in Florence in the 1930s. Alfred, an Englishman who moved to that city in order to write a book on Giotto, meets a boy who is fond of music and mathematics, with whom he becomes close friends. Alfred goes to Switzerland, but one day he receives an anguished letter from the boy and rushes back to Florence where he learns some terrible news.