A cheating husband is charged in the poisoning death of his invalid wife, in spite of other women and suicide also being suspected.

Frankenstein's unscrupulous colleague, Dr. Bohmer, plans to transplant Ygor's brain so he can rule the world using the monster's body, but the plan goes sour when he turns malevolent and goes on a rampage.

A convicted thief in Dartmoor prison hides the location of the stolen Bank of England printing plates inside three music boxes. When the innocent purchasers of the boxes start to be murdered, Holmes and Watson investigate.

Bill Saunders, a former prisoner of war living in England, whose experiences have left him unstable and violent, gets into a bar fight in which he kills a man and then flees. He hides out with the assistance of a nurse, Jane Wharton, who believes his story that the killing was an accident.

Struggling artist Geoffrey Carroll meets Sally while on holiday in the country. A romance develops, but he doesn't tell her he's already married. Suffering from mental illness, Geoffrey returns home where he paints an impression of his wife as the angel of death and then promptly poisons her. He marries Sally but after a while he finds a strange urge to paint her as the angel of death too and history seems about to repeat itself.

London, 1761. St. Mary's of Bethlehem, a sinister madhouse, is visited by wealthy people who enjoy watching the patients confined there as if they were caged animals. Nell Bowen, one of the visitors, is horrified by the deplorable living conditions of the unfortunate inhabitants of this godforsaken place, better known as Bedlam.

England, at the start of World War Two. Mysterious wireless broadcasts, apparently from Nazi Germany are heard over the BBC. They warn of acts of terror in England, just before they take place. Baffled, the Defense Committee call in Sherlock Holmes.

The famous Borgia Pearl, a valuable gem with a history of bringing murder and misfortune to its owner since the days of the Borgias, is brought to London, thanks in part to Sherlock Holmes. But before long the jewel is stolen, due to an error on Holmes' part, and shortly thereafter, a series of horrible murders begin, the murderer leaving his victims with their spines snapped and surrounded by a mass of smashed china.

The owner of a coal mining operation, falsely imprisoned for fratricide, takes a drug to make him invisible, despite its side effect: gradual madness.

A fugitive, dangerous madman reaches an English village where he confronts his former partner who left him for dead in the jungle after their discovery of a diamond mine. When the former partner also claims to have since lost the mine and all its wealth, which he took all for himself, and though the partner is still living in a state of luxury , the madman takes up an offer from a crazed scientist to make him invisible, something the scientist has already done with experimental animals, so that he can take revenge.