A British woman visits her husband at the Mexican mine he is attempting to reopen and discovers that the workers refuse to enter the mine, fearing an ancient curse. The couple enter the mine to prove there is no danger and inadvertently release a demon which possesses people's left hands and forces them to behave in a suitably diabolical manner.

After a brief flash-forward to Frank Sinatra as an old man, saying "I miss my guys," the movie's main narrative begins during high points in the solo careers of the Rat Pack: Dean Martin has become a big success despite the breakup of his partnership with Jerry Lewis; Sinatra's career is at its peak; Sammy Davis, Jr., is making a comeback after a near fatal car crash, and standup comic Joey Bishop is gaining exposure as an opening act for the other three. The Pack becomes complete when Sinatra reconciles with actor Peter Lawford, who has been ostracized since being seen out publicly with Sinatra's ex-wife, Ava Gardner.

A convicted rapist continually violates his parole but slips through the cracks of the justice system until his crimes escalate into a frenzy of terror against five helpless women.

After being discharged from the Army, Brian Flanagan moves back to Queens and takes a job in a bar run by Doug Coughlin, who teaches Brian the fine art of bar-tending. Brian quickly becomes a patron favorite with his flashy drink-mixing style, and Brian adopts his mentor's cynical philosophy on life and goes for the money.