Two correspondence school detectives attempt to apprehend a maniac on the loose and get him back to the asylum.

Mr. Dithers is trying to encourage a businessman to build a war-time manufacturing plant on land he owns while Dagwood tries to prevent the businessman from learning his daughter is involved in a local theatre production.

Marjorie Beebe give advice to the lovelorn service over the air, but she almost fails when she tries to get a man of her own.

A writer takes a job as a secretary because her scrupulous husband isn't bringing in the dough as an attorney. When her new employer is murdered, she can't seem to make up her mind as to whether she "dunnit" or not.

The arrival of the telegraph put Pony Express riders like John Blair and his pal Smoky out of work. A race will decide whether they or stageline owner Drake get the government mail contract.

Leon Erroll drinks too much, in the opinion of his mother-in-law, Dot Farley. So she arranges for everyone around him to talk in non-sequiturs until he decides to sober up permanently.

It's 1861 and Buck gets the business men of Sacramento to establish the Pony express. Hawley runs the stage line over the same route and has the U. S. mail contract. When it looks like the Pony Express will be awarded the mail contract, he gives guns to the Indians and has them attack both the riders and the stations.

Apple Annie is an aging New York City fruit seller whose daughter Louise has been raised in a Spanish convent since she was an infant. As she grows up, Louise is led to believe that her mother is a society matron called Mrs. E. Worthington Manville. Annie worries that her lie is in danger of being uncovered when she learns that Louise is sailing to New York with her new fiancé and his nobleman father.

President Lincoln personally sends Bill Gibson west to see if he can stop the holdups of the needed shipments of gold. There he meets his boyhood friend Foster. When all others refuse to take out the next gold shipment due to the killings, Bill volunteers. Jeannie, afraid for his safety, tells Foster of Bill's secret route not knowing Foster is the leader of the outlaw gang.

A high priest of Karnak travels to America with the living mummy Kharis (Lon Chaney Jr.) to kill all those who had desecrated the tomb of the Egyptian princess Ananka thirty years earlier.