In 1750, in the glare of the Caribbean, the man who created history known as the forerunner of independence in Venezuela. His name is Francisco de Miranda and, to be exact, is the largest globetrotter who has known the Americas, Miranda has a reputation as an inveterate wanderer, an eternal conspirator, a turncoat, a conqueror of nobles and courtiers, a lover of asylums, libraries, prisons and brothels, has written 63 volumes of his autobiography, a friend of princes, military and world-renowned artists, collector of women and unthinkable dreams, restless fugitive, owner of ten different names, and presented by the British press the moment as the future liberator of Spanish America.

In 1856, a whaler arrives in Paita, Peru; on board is Herman Melville, who is astonished to learn that Manuela Sáenz, for eight years the lover of Simón Bolívar, is still alive. He calls on her, and although she will not talk to him about her life, his visit sends her to her chest of Bolívar's letters. As she reads them, the sepia-toned present gives way to flashbacks in color: she meets 'the Liberator' in 1822, becomes his lover, and also becomes a colonel in his military movement to realize the 'Gran Colombia', one nation across South America. As plague (brought by the ship) closes in on Manuela's household, so does her tempestuous story move toward Bolívar's betrayal and death.

Salserín, la primera vez, candidly recounts a story of teenage love framed in the genesis of a salsa band that was once a musical phenomenon in the mid-nineties.

José Gregorio Hernández (Flavio Caballero) was a doctor who dedicated his life to serving the poor, the sick and the dispossessed in times when no one took them into account. Every day he attended to a large number of people who required his services without charging fees, which gave him great fame in the population.