Sister Italy is a heartfelt, hilarious, culinary escapade that follows the fortunes of two Italian-American sisters, Italia and Maria, who are rival cooks. They clash in an intriguing cooking competition.

The marriage of mutual friends reunites former college roommates Bob and Brendan, who tried to ignore the sexual tension that always flowed between them. Brendan finally comes out to Bob at the reception, but is it a case of too little, too late?