A disillusioned Johannesburg street thug rescues an orphaned child with uncontrollable supernatural powers. On the run, he must help the sickly boy master his gift before a superstitious family member finds them.

A young South African boy from the Johannesburg ghetto named Tsotsi, meaning Gangster, leaves home as a child to get away from his helpless parents. Now a teenage thug, Tsotsi finds a baby in the back seat of a car he's just stolen. He decides that it is his responsibility to care for the infant and in the process learns that maybe the criminal life isn’t the best way.

Inspired by true events, this film takes place in Rwanda in the 1990s when more than a million Tutsis were killed in a genocide that went mostly unnoticed by the rest of the world. Hotel owner Paul Rusesabagina houses over a thousand refuges in his hotel in attempt to save their lives.