When her wild younger sister Ashley, who suffers from bipolar disorder and drug addiction, goes missing, Libba Phillips pours all her time and energy into finding Ashley and bringing her home. As the years go by, Libba refuses to give up hope, and, at the expense of her marriage and career, Libba finds her calling in life: creating a much-needed resource center for other families whose missing loved ones have fallen through the cracks.

On the outside, Helen has it all – a loving family and a successful career – but when her suppressed mental illness resurfaces, the world crumbles around her. Crippled by depression, Helen finds solace through her friendship with Mathilda, a kindred spirit struggling with bipolar disorder.

A lawyer prosecuting a man accused of killing his wife must battle with her emotions due to the similarities to the death of her own mother.