Carla believes her missing daughter is attempting to make contact through mysterious means, her husband Brian pushed aside, Carla is on a path of discovery, but may be one that is best left alone.

In 1926, Newt Scamander arrives at the Magical Congress of the United States of America with a magically expanded briefcase, which houses a number of dangerous creatures and their habitats. When the creatures escape from the briefcase, it sends the American wizarding authorities after Newt, and threatens to strain even further the state of magical and non-magical relations.

12-year-old Conor encounters an ancient tree monster who proceeds to help him cope with his mother's terminal illness and being bullied in school.

Hobbs has Dominic and Brian reassemble their crew to take down a team of mercenaries; Dominic unexpectedly gets sidetracked with facing his presumed deceased girlfriend, Letty.