In the polarized and violent Medellín (Colombia's 'City of Eternal Spring') of the 1970s, doctor Héctor Abad Gómez is concerned about both his children and children from less favored classes. After a devastating loss in the family, Héctor gives himself to the greater cause of public health programs for the poor in Medellín to the consternation of the city's authorities.

For Pablo Escobar family is everything. When young surfer Nick falls for Escobar's niece, Maria, he finds his life on the line when he's pulled into the dangerous world of the family business.

Lucas and Simón, friends who work in a creative agency in Bogotá, throw a party as a favor to their boss, Johana. There, Lucas meets Lina, Johana's paisa cousin who travels to Bogotá to get a visa and go to study fashion design in the United States. Madly in love, Lucas travels to Medellin to try to conquer Lina, where he will realize that Before conquering her, she will have to conquer her paisa family.